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December 1 2015 at 4:00 PM
Law School
Wayne State University's Department of Economics welcomes students and the campus community to the formal launch of its newest course: Introduction to Venture Capital and Social Impact Investing; the first of its kind in the College of Liberal Arts and Sciences. Come preview this experiential learning opportunity which will provide students with an insider look at the venture capital industry and social impact investing. Tuesday, December 1st 4 p.m. Spencer Partrich Auditorium, Law School Event schedule: 4 - 6 p.m. Opening remarks and private screening of SOMETHING VENTURED, a documentary film about the birth of the venture capital industry. 6 - 7 p.m. Panel discussion with industry experts who will discuss careers in private equity investing and the venture capital landscape in Michigan. 7 - 8 p.m. Reception and networking with venture capital industry experts
Know Your Value: Learn to Ask for What You're Worth
December 2 2015 at 12:00 PM
Undergraduate Library, David Adamany
Why arent women always paid what theyre worth? In surveys, 2.5 times more women than men said they feel "a great deal of apprehension" about negotiating. Join us for this interactive program that continues the conversation about the skills and awareness everyone needs to have to advance their career. 
Lipids@Wayne with Monica Driscoll PhD Dec2
December 2 2015 at 5:00 PM
Biological Sciences
Lipids@Wayne and the Office of the Vice President for Research are pleased to announce the next Lipids@Wayne seminar on Wednesday, December 2, 2015 at 5:00 pm in 1167 Biological Science Building.  The seminar is free and open to the public.  Refreshments will be served. Speaker: Monica Driscoll Ph.D. Title: A Novel Mechanism for Keeping Neurons Young Abstract: Toxicity of misfolded proteins and mitochondrial dysfunction are pivotal factors that promote age-associated functional neuronal decline and neurodegenerative disease.  Accordingly, neurons invest considerable cellular resources in chaperones, protein degradation, autophagy, and mitophagy to maintain proteostasis and energy/redox balance while avoiding neurotoxicity.  Although these neurotoxic challenges have long been considered to be cell-intrinsic, evidence now supports that both misfolded human disease proteins and mitochondria originating in one neuron can appear in neighboring cells, a phenomenon proposed to promote pathology spread.  We have discovered a previously unknown capacity of C. elegans adult neurons to extrude large (~5 um) vesicles that include substantial amounts of cytoplasmic contents via a dynamic process requiring specific cytoskeletal proteins and motors.  These "exopher" vesicles can include fluorescent GFP or mCherry, loaded Dil, aggregated human proteins such as an expanded Q128 polyglutamine protein, lysosomes, and/or mitochondria.  Aggregated protein and oxidized mitochondria can be preferentially segregated into exophers, and neurons that extrude exophers generally function better than those that do not.  Inhibiting chaperone expression or autophagy, as well as compromising mitochondrial quality, enhances exopher prevalence, revealing exopher-genesis as a response to stresses in proteostasis and organelle maintenance.  Finally, extruded exopher contents can be found in both neighboring and remote cells, and thus exophers can contribute to a neuronal "contagion" mechanism.  We speculate that exophers are components of a conserved mechanism that constitutes a fundamental, but formerly unrecognized, branch of proteostasis and mitochondrial quality control, which, when imbalanced, might actively contribute to the spread of toxic species relevant to pathogenesis in human disease.  
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Office of Government and Community Affairs
4145 Faculty/Administration Building, 656 West Kirby • Detroit, MI 48202
Tel: (313) 577-5284 • Fax: (313) 577-0848